Product Details
Catalog Number: MO15134
Applications: WB
Type: Mouse IgG
Dilutions: Western Blot: 1 ug/ml
Immunogen: Mouse myeloma cell line NS0-derived recombinant human BMP?4 Ser293-Arg408
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein A purified
Format B: liquid
Species Reactivity: Human, Primate
Entrez: 652
UniProt: P12644
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$339.00Add to Cart

BMPs are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily and were originally identified as regulators of cartilage and bone formation. There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs. Biologically active BMPs are usually homodimers containing a characteristic cysteine knot structure. Heterodimers, BMP-2/BMP-7 and BMP-4/BMP-7 have also been suggested to exist and function in vivo. They are more potent inducers of bone formation than their respective homodimers. In addition, heterodimers, but not homodimers, are ventral mesoderm inducers. Heterodimer activity may be mediated by a different or additional receptor subtype.

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