Chordin-like 2 (CHL2; also known as breast tumor novel factor 1/BNF-1), is a secreted glycoprotein that has significant homology to chordin and acts as a TGF-beta superfamily antagonist. CHL2 is a chordin family member with structural homology to CHL1 (also known as neuralin or ventroptin). Mouse CHL2401 cDNA encodes a 45‑50 kDa, 426 amino acid (aa) residue precursor protein with a putative 25 aa signal peptide and a 401 aa mature segment. The mature segment contains three 63 aa cysteine-rich von Willebrand type C repeats (CRs) that are conserved among chordin family members in the spacing of 10 cysteine residues. It also contains two potential N-linked glycosylation sites and one putative NLS that lies just proximal to the third CR repeat.
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