CD45 antigen is a protein which is a leucocyte common antigen, a type I transmembrane protein present on all differentiated hematopoietic cells except erythrocytes that assists in the activation of those cells (a form of co-stimulation). It is expressed in lymphomas, B-cell chronic lymphocytic leukemia, hairy cell leukemia, and acute nonlymphocytic leukemia.
Studies have shown that expression of CD 45 is elevated in microglia in AD brain compared with controls.
Image: CD45 staining of paraffin-embedded human tonsil.
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