Cathepsin G expression in normal tissues is restricted to granulocytes, especially neutrophils. However, mononuclear phagocytes have been demonstrated to bind and internalize proteases from neutrophils. Cathepsin G is located in neutrophilic polymorphonuclear leukocytes which contain specialized azurophil granules together with two other serine proteases; elastase and hepsin. These three proteases may participate in the killing and digestion of engulfed pathogens and in connective tissue remodeling at sites of inflammation. Cathepsin G is also reported to be expressed in acute and chronic myeloid leukemias whereas acute lymphoblastic or chronic lymphocytic leukemias are negative for this protein.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size CARD8 RA30062 50 ug CARD9 RA30063 50 ug Caspase-14 RA30061 50 ug Caspase-3 (C terminal region) RA21011 50 ug Caspase-3 (N terminal region) RA21012 100 ug Caspase-3, active RA15046 50 ug Caspase-7 MO25036 100 ul Cathepsin B (Mouse) GT15047 100 ug Cathepsin D GT15042 100 ug Cathepsin L (Human) GT15048 100 ug Cathepsin L (Mouse) GT15049 100 ug