Aldolase A is generally considered to be a muscle enzyme. Northern analysis of cultured cells suggests that it is present in both neurons and glia. Aldolase C shares 81% amino acid identity with aldolase A and 70% identity with aldolase B.
Earlier studies using isozyme-specific antibodies report its location in gray matter astrocytes and cells of the pia mater. In situ hybridization of mouse central nervous system using isozyme-specific probes revealed that aldolase A and C are expressed in complementary cell types: aldolase A mRNA is found in neurons; aldolase C message is detected in astrocytes, some cells of the pia mater, and Purkinje cells. Aldolase C can in some situations be used as an astrocyte marker. However Purkinje cells of the cerebellum contain high levels of the enzyme, so the enzyme is not totally astrocyte specific.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size ALDH1L1 RA22119 100 ul Coronin 1a/p57 RA22108 100 ul GAP43 RA22115 100 ul GFAP CH22102 100 ul GFAP RA22101 100 ul Glial Fibrillary Acidic Protein (GFAP) MO22101 100 ul IBA1 Polyclonal Rabbit Antibody RA22133 100 ul SOX-2/SRY (sex determining region Y)-box 2 MO47038 100 ul SRY (Sex Determining Region Y)-Box 11/SOX-11 MO47052 100 ul Vimentin CH22108 100 ul Vimentin MO22115 100 ul Vimentin RA22124 100 ul of Serum