Nestin is a member of the class IV intermediate filament protein family which is expressed in neuroepithelial stem cells. The protein proved to be an unusual member of the intermediate filament family, containing an α-helical region homologous to that found in keratin and neurofilament subunits. The nestin protein has a very short non-helical N-terminal region followed by the α-helical region and a very long and repetitive C-terminal region. Nestin is expressed by radial glia and other types of dividing cells in the developing central and peripheral nervous systems and in developing muscle.
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- Jie L. Tian, Chia-Wei Huang, Farzad Eslami, Michael Philip Mannino, Rebecca Lee Mai, and Gerald W. Hart. (2023). Regulation of Primary Cilia Length by O-GlcNAc during Neuronal Development in Human Neuron Model. Preprints. doi: 10.20944/preprints202304.0345.v1
- Bai Xu, Man Yin, Yaming Yang, Yunlong Zou, Wenbin Liu, Lianyong Qiao, Jixiang Zhang, Zhan Wang, Yayu Wu, He Shen, Minghan Sun, Weiyuan Liu, Weiwei Xue, Yongheng Fan, Qi Zhang, Bing Chen, Xianming Wu, Ya Shi, Falong Lu, Yannan Zhao, Zhifeng Xiao, and Jianwu Dai. (2023). Transplantation of Neural Stem Progenitor Cells from Different Sources for Severe Spinal Cord Injury Repair in Rat. Bioactive Materials, 23:300-313. doi: 10.1016/j.bioactmat.2022.11.008
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