In late 2019 a novel infectious disease was discovered in Wuhan, China which was quickly recognized to be caused by a previously unknown RNA coronavirus. The virus was very rapidly isolated, the full RNA sequence determined and put on-line on the 10th of January 2020. The sequence revealed that the virus was most closely related to certain bat coronaviruses and the severe acute respiratory syndrome (SARS) coronavirus. Immediately biotechnology companies and research institutes used the RNA sequence information to generate vaccine candidates. The SARS virus was known to enter and infect human cells by means of the so-called spike or S-protein which binds to the extracellular domain of the angiotensin converting enzyme 2 (ACE2) protein, which is then internalized bringing the virus into the cell. Cryoelectron microscopy and binding studies quickly determined that the S-protein of SARS-CoV2 is structurally similar to to that of the SARS virus and also binds to the ACE2 receptor, albeit with higher affinity than the S-protein of SARS.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size SARS-CoV2 S-Protein ACE2 Binding Domain MO22198 100 ul SARS-CoV2 S-Protein ACE2 Binding Domain RA22140 100 ul Virus Transport Media VTM VTM-2: 3 ml VTM in 15 ml tube Virus Transport Media VTM VTM-3: 50 ml Virus Transport Media VTM VTM-4: 100 ml Virus Transport Media VTM VTM-5: 500 ml Virus Transport Media VTM VTM-6: 1000 ml Virus Transport Media with Swabs VTM-Kit VTM-Kit: Tube w/ 3 ml VTM, sterile swab, bhz bag (min. 100) Virus Transport Media with Swabs VTM-Kit VTM-with-Swab: 12 ml tube with 3 ml VTM and sterile swab