Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons and are composed predominantly of three major proteins called NF-L, NF-M and NF-H, though other filament proteins, but in certain cell types and during development α-internexin, peripherin, nestin and vimentin may be included also. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at 68-70kDa with some variability across species. Antibodies to NF-L are useful for identifying neuronal cells and their processes in cell culture and sectioned material. NF-L antibody can also be useful for the visualization of neurofilament rich accumulations seen in many neurological diseases, such as Lou Gehrig’s disease (ALS), giant axon neuropathy, Charcot-Marie Tooth disease and many other.
The antibody was made against a preparation of recombinant full length human NF-L protein expressed in and purified from E. coli. This antibody is known to bind NF-L from a variety of species including human, rat and mouse, and the epitope is 100% conserved in all mammalian NF-L sequences, so this antibody will have wide applicability.
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