The synaptojanin family comprises proteins that are key players in the synaptic vesicle recovery at the synapse. Synaptojanin 1 is an inositol 5-phosphatase which exists in two tissue specific isoforms (170 and 145 kDa). Through its interactions with a variety of proteins and molecules is thought to play a role in the development of nervous systems. These include TrkA, proNGF and AMPA.
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