Product Details
Catalog Number: MO30000
Applications: IHC
Type: Mouse IgG
Immunogen: Bovine MAP2
Storage: Store at 4°C short term. Aliquot and store at -20-70°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: liquid
Species Reactivity: Human, Mouse, Porcine
Entrez: 4133
UniProt: P11137
Downloads: SDS (pdf)
Downloads: Datasheet (pdf)
Product Sizes
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50 ul$399.00Add to Cart

Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein tau and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4, and MAP5. MAP2 is made up of two ~280kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein tau. MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. Antibodies to MAP2 are therefore excellent markers on neuronal cells, their perikarya and neuronal dendrites. In contrast, tau is found predominantly in neuronal axons.

Images
MAP-2 (dilution: 10 ug/ml ) staining of Human Brain, Cortex (formalin-fixed, paraffin-embedded) followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.

MAP-2 (dilution: 10 ug/ml ) staining of Human Brain, Cortex (formalin-fixed, paraffin-embedded) followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.

MAP-2 (dilution: 10 ug/ml ) staining of Human Brain, Cortex (formalin-fixed, paraffin-embedded) followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.

MAP-2 (dilution: 10 ug/ml ) staining of Human Brain, Cortex (formalin-fixed, paraffin-embedded) followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.