Product Details
Catalog Number: MO30003
Applications: WB, IHC, E
Type: Mouse IgG
Dilutions: ICC 1:500 -1:1000; IHC 1:500 -1:1000; WB 1:5,000 - 1:10,000
Immunogen: SMG1 / ATX antibody was raised against sMG1 (-, 2922 a.a. ~ 3032 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Storage: Store at 4°C short term. Aliquot and store at -20-70°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Protein A purified
Format B: liquid
Species Reactivity: Human
Entrez: 7139
UniProt: P45379
Downloads: Datasheet (pdf)
Product Sizes
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100 ug$435.00Add to Cart

SMG1 encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. This protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein.

The absence of a protein called SMG1 could be a contributing factor in the development of Parkinson's disease and other related neurological disorders, according to a study led by the Translational Genomics Research Institute (TGen). http://medicalxpress.com/news/2013-10-absence-smg1-protein-contribute-parkinson.html

Images

Immunoperoxidase of monoclonal antibody to SMG1 on formalin-fixed paraffin-embedded human adrenal gland. [antibody concentration 1.5 ug/ml inset: : Western blot of SMG1 expression in HeLa NE.

Immunoperoxidase of monoclonal antibody to SMG1 on formalin-fixed paraffin-embedded human adrenal gland. [antibody concentration 1.5 ug/ml inset: : Western blot of SMG1 expression in HeLa NE.

Detection limit for recombinant GST tagged SMG1 is approximately 0.1 ng/ml as a capture antibody.

Detection limit for recombinant GST tagged SMG1 is approximately 0.1 ng/ml as a capture antibody.