Arginase-1 is a cytosolic metalloenzyme encoded by the ARG1 gene and is expressed primarily in hepatocytes. The type I isoform of Arginase-1 mediates the urea cycle by catalyzing the hydrolysis of arginine to urea and ornithine. A deficiency in the arginase-1 enzyme is associated with Argininemia, an inherited autosomal recessive disorder characterized by an excess of arginine and ammonia in the bloodstream (hyperammonemia). MO47024 Antibody is validated for the detection of Arginase-1 (ARG1). ARG1 is often used as a specific marker to distinguish benign and malignant hepatic tumors as it is highly specific for hepatocytes.
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