PSD-95 or SAP90 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. PSD-95 is a excellent marker for post synpatic mechanisms.
Note: This antibody has been developed by UC Davis under a grant by NIH.
- Product Reviews
- Product Publications
- Farina J. Mahmud, Thomas Boucher, Shijun Liang, and Amanda M. Brown. (2020). Osteopontin and Integrin Mediated Modulation of Post-Synapses in HIV Envelope Glycoprotein Exposed Hippocampal Neurons. Brain Sciences, 10(6), 346. doi: 10.3390/brainsci10060346
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products