GABAA receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters.They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics.
The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho.(Genome Res. 16 (1): 55–65). Defects in GABA A R, delta (GABRD) gene are associated Ataxi and Generalized Epilepsy.
This antibody has been developed by UC Davis under a grant by NIH.