Product Details
Catalog Number: MO50004
Applications: ICC, WB, IHC
Type: Mouse IgG
Immunogen: Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (also known as metabotropic glutamate receptor 5, accession number P31424).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: Supernatant
Species Reactivity: Human, Mouse, Rabbit
Entrez: 2911
UniProt: Q13255
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$405.00Add to Cart

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms, and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involved in synaptic plasticity underlying learning and memory as well as chronic pain.

mGluR1/5 is an  important positive modulators of synaptic function and neuronal activity. Dysregulation of mGluR1/5 signaling is implicated in some disorders of neurodevelopment, including fragile X syndrome(the most common inherited form of intellectual disabilities and the leading cause of autism. In adults, mGluR1/5 related pathologies could contribute to depression, epilepsy and pain signaling.

Note: This antibody has been developed by UC Davis under a grant by NIH.

Images
mGluR1/5 staining of adult rat hippocampus.

mGluR1/5 staining of adult rat hippocampus.

mGluR1/5 staining of adult rat hippocampus.

mGluR1/5 staining of adult rat hippocampus.

mGluR1/5 western blots on membranes prepared from whole mouse (MBM) and rat (RBM) brain, and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)], and hippocampus [HBM(H)].

mGluR1/5 western blots on membranes prepared from whole mouse (MBM) and rat (RBM) brain, and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)], and hippocampus [HBM(H)].

mGluR1/5 western blots on membranes prepared from whole mouse (MBM) and rat (RBM) brain, and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)], and hippocampus [HBM(H)].

mGluR1/5 western blots on membranes prepared from whole mouse (MBM) and rat (RBM) brain, and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)], and hippocampus [HBM(H)].