Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors activated by glutamate. Based on sequence similarity, transduction mechanisms, and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8. mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells. mGluRs have been suggested to play a variety of functional roles, among which is involved in synaptic plasticity underlying learning and memory as well as chronic pain.
mGluR1/5 is an important positive modulators of synaptic function and neuronal activity. Dysregulation of mGluR1/5 signaling is implicated in some disorders of neurodevelopment, including fragile X syndrome(the most common inherited form of intellectual disabilities and the leading cause of autism. In adults, mGluR1/5 related pathologies could contribute to depression, epilepsy and pain signaling.
Note: This antibody has been developed by UC Davis under a grant by NIH.