Product Details
Catalog Number: MO50006
Applications: ICC, WB, IHC
Type: Mouse IgG
Immunogen: Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2 (accession number P15381).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Supernatant
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 775
UniProt: Q13936
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$349.00Add to Cart

CaV2.1 Ca2+ channel (also known as Voltage-gated/dependent T-type calcium channel alpha-1 subunit, and CACNA1C) encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. It binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

In the heart, CAV2.1  may be involved in pacemaker current. It also inhibits thalamic sensory transmission to promote sleep. CAV2.1 could play a role in pain processing and neuro-disorders such as migraines, epilepsy and cerebellar ataxias

Note: This antibody has been developed by UC Davis under a grant by NIH.

Images
Cav1.2 Ca2+ channel staining of adult rat hippocampus

Cav1.2 Ca2+ channel staining of adult rat hippocampus

Cav1.2 Ca2+ channel staining of adult rat hippocampus

Cav1.2 Ca2+ channel staining of adult rat hippocampus

Cav2.1 Ca2+ channel western blots of adult rat brain membrane.

Cav2.1 Ca2+ channel western blots of adult rat brain membrane.

Cav2.1 Ca2+ channel western blots of adult rat brain membrane.

Cav2.1 Ca2+ channel western blots of adult rat brain membrane.