Product Details
Catalog Number: MO50007
Applications: ICC, WB, IHC
Type: Mouse IgG
Immunogen: Synthetic peptide amino acids 859-875 (N-terminus) of rat Cav1.3 (also known as voltage-dependent L-type calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 776
UniProt: Q01668
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$349.00Add to Cart

Cav1.3 Ca2+ channel or CACN4 encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Cav1.3 voltage-gated L-type calcium channels (LTCCs) translate sound-induced depolarization into neurotransmitter release in auditory hair cells and control diastolic depolarization. 

These channels also play a major role in the generation of cardiac pacemaker activity by contributing to diastolic depolarization in SAN pacemaker cells. Genetic knockout or pharmacological inhibition of Cav1.3 reverts this dependency back to HCN and protects these neurons in mouse models of Parkinson’s disease in adult mice.

Note: Antibody has been developed by UC Davis under a grant by NIH.

Images
Cav1.3 Ca2+ channel staining of adult rat hippocampus.

Cav1.3 Ca2+ channel staining of adult rat hippocampus.

Cav1.3 Ca2+ channel staining of adult rat hippocampus.

Cav1.3 Ca2+ channel staining of adult rat hippocampus.

Cav1.3Ca2+ channel western blots of adult rat brain membrane.

Cav1.3Ca2+ channel western blots of adult rat brain membrane.

Cav1.3Ca2+ channel western blots of adult rat brain membrane.

Cav1.3Ca2+ channel western blots of adult rat brain membrane.