TRPC4 (Transient receptor potential cation channel, subfamily C, member 5) is one of 7 mammalian TRPC proteins. It forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation including angiogenesis.
TRPC4 could contribute to late onset Alzheimer's and certain Cardiovascular Diseases.
Note: This antibody has been developed by UC Davis under a grant by NIH.
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