TRPC5 (Transient receptor potential cation channel, subfamily C, member 5) is one of 7 mammalian TRPC proteins. It functions as an innocuous cold transducer in nociceptive and thermosensory nerve endings. It plays a role in the activiating the channel for semaphorin 3A-induced neuronal growth cone collapse
TRPC5 mediated Rho GTPase signaling may cause podocyte damage, and TRPC channels may therefore provide a novel target for anti-proteinuric therapies in acquired, Angiotensin-associated proteinuric disease such as hypertensive and/or diabetic nephropathy.
Note: This antibody has been developed by UC Davis under a grant by NIH.
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