Product Details
Catalog Number: MO50010
Applications: WB, IHC, IP, IF
Type: Mouse IgG
Immunogen: Synthetic peptide amino acids 827-845 (SKAESSSKRSFMGPSLKKL) of human TrpC5 (also known as short transient receptor potential channel 5 and Htrp5,
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 7224
UniProt: Q9UL62
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$405.00Add to Cart

TRPC5 (Transient receptor potential cation channel, subfamily C, member 5)  is one of 7 mammalian TRPC proteins. It functions as an innocuous cold transducer in nociceptive and thermosensory nerve endings. It plays a role in the activiating the channel for semaphorin 3A-induced neuronal growth cone collapse

TRPC5 mediated Rho GTPase signaling may cause podocyte damage, and TRPC channels may therefore provide a novel target for anti-proteinuric therapies in acquired, Angiotensin-associated proteinuric disease such as hypertensive and/or diabetic nephropathy.

Note: This antibody has been developed by UC Davis under a grant by NIH.

Images
TRPC5 is present in adult human skin intraepithelial nerves (arrows); dotted line indicates basement membrane. (Inset) TRPC5 channel (doi:10.1073/pnas.1115387108).

TRPC5 is present in adult human skin intraepithelial nerves (arrows); dotted line indicates basement membrane. (Inset) TRPC5 channel (doi:10.1073/pnas.1115387108).

TRPC5 is present in adult human skin intraepithelial nerves (arrows); dotted line indicates basement membrane. (Inset) TRPC5 channel (doi:10.1073/pnas.1115387108).

TRPC5 is present in adult human skin intraepithelial nerves (arrows); dotted line indicates basement membrane. (Inset) TRPC5 channel (doi:10.1073/pnas.1115387108).

TRPC5 staining of cerebellar (A), reticular thalamic nucleus (B) and .hippocampal (C) tissue.

TRPC5 staining of cerebellar (A), reticular thalamic nucleus (B) and .hippocampal (C) tissue.

TRPC5 staining of cerebellar (A), reticular thalamic nucleus (B) and .hippocampal (C) tissue.

TRPC5 staining of cerebellar (A), reticular thalamic nucleus (B) and .hippocampal (C) tissue.

Immunoprecipitation analysis of TRPC5 protein in brain microsomes extracted from wild-type (WT) and TRPC5 knockout (KO) littermates. Courtesy of Dr. David Clapham (HHMI/Harvard Medical School).

Immunoprecipitation analysis of TRPC5 protein in brain microsomes extracted from wild-type (WT) and TRPC5 knockout (KO) littermates. Courtesy of Dr. David Clapham (HHMI/Harvard Medical School).

Immunoprecipitation analysis of TRPC5 protein in brain microsomes extracted from wild-type (WT) and TRPC5 knockout (KO) littermates. Courtesy of Dr. David Clapham (HHMI/Harvard Medical School).

Immunoprecipitation analysis of TRPC5 protein in brain microsomes extracted from wild-type (WT) and TRPC5 knockout (KO) littermates. Courtesy of Dr. David Clapham (HHMI/Harvard Medical School).