Product Details
Catalog Number: MO50011
Applications: ICC, IHC, IP
Type: Mouse IgG
Immunogen: Fusion protein amino acids 1-216 (full length) of rat KChIP1b (accession number Q8R426).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Zebrafish, Xenopus
Entrez: 30820
UniProt: Q9NZI2
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$349.00Add to Cart

Four KChIP proteins constitute the fifth subfamily (Class E) and are unique to mammals. KChIPs interact with voltage-gated potassium channels and presenilins [5-8]. KChIP1, KChIP3, KChIP4 are expressed predominantly in brain, while KChIP2 is highly expressed in both heart and brain.

K+ channel interacting protein 1 (KChIP1) is a neuronal calcium sensor (NCS) protein that interacts with multiple intracellular molecules. It regulates behavioral anxiety by modulating inhibitory synaptic transmission, and drugs that act on KChIP1 may help to treat patients with mood disorders including anxiety.

Note: Antibody has been developed by UC Davis under a grant by NIH.

Images
KChIP1 staining of adult rat hippocampus.

KChIP1 staining of adult rat hippocampus.

KChIP1 staining of adult rat hippocampus.

KChIP1 staining of adult rat hippocampus.