Four KChIP proteins constitute the fifth subfamily (Class E) and are unique to mammals. KChIPs interact with voltage-gated potassium channels and presenilins [5-8]. KChIP1, KChIP3, KChIP4 are expressed predominantly in brain, while KChIP2 is highly expressed in both heart and brain.
K+ channel interacting protein 2(KChIP2)modulates multiple KV and NaV currents suggesting that KChIP2 is a multi-modal regulator of cardiac ionic currents.
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