Kv1.2 K+ channels mediate the voltage-dependent potassium ion permeability of excitable membranes and are uniformly distributed in the heart and brain. Kv1.2 play diverse functional roles in several neuronal compartments, especially in the regulation of pre- and post-synaptic membrane excitability. Kv1.2 subunits can co-localize with other Kv1 subunits. For example, Kv1.2 colocalizes with Kv1.1 in the nodes of Ranvier in myelinated axons, and in the brain.
Changes in K+ channel function have been associated with cardiac hypertrophy and failure, apoptosis and oncogenesis, and various neurodegenerative and neuromuscular disorders.
Note: Antibody has been developed by UC Davis under a grant by NIH.
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