Product Details
Catalog Number: MO50017
Applications: ICC, WB, IHC, IP
Type: Mouse IgG
Immunogen: Synthetic peptide amino acids 485-506 (GGMNHSAFPQTPFKTGNSTATC, cytoplasmic C-terminus of rat Kv1.3, accession number P15384).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 3738
UniProt: P22001
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$349.00Add to Cart

Kv1.3 K+ channels heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. All human T cells express roughly 300 Kv1.3 channels per cell along with 10-20 calcium-activated KCa3.1 channels. Kv1.3 blockers have prevented and treated disease in rat models of multiple sclerosis, type-1 diabetes mellitus, rheumatoid arthritis, contact dermatitis and delayed type hypersensitivity

Changes in K+ channel function have been associated with cardiac hypertrophy and failure, apoptosis and oncogenesis, and various neurodegenerative and neuromuscular disorders.

Note: Antibody has been developed by UC Davis under a grant by NIH.

Images
Kv1.3 staining of (A)adult rat dentate gyrus and (B) hippocampus.

Kv1.3 staining of (A)adult rat dentate gyrus and (B) hippocampus.

Kv1.3 staining of (A)adult rat dentate gyrus and (B) hippocampus.

Kv1.3 staining of (A)adult rat dentate gyrus and (B) hippocampus.

Kv1.3 western blots of rat brain membranes(RBM), and adult mouse brain membranes from two Kv1.3 knockout mice (MBM-Kv1.3-KO) and one wild-type mouse (MBM-WT). KO samples courtesy of Dr. Leonard Kaczmarek, Yale School of Medicine.

Kv1.3 western blots of rat brain membranes(RBM), and adult mouse brain membranes from two Kv1.3 knockout mice (MBM-Kv1.3-KO) and one wild-type mouse (MBM-WT). KO samples courtesy of Dr. Leonard Kaczmarek, Yale School of Medicine.

Kv1.3 western blots of rat brain membranes(RBM), and adult mouse brain membranes from two Kv1.3 knockout mice (MBM-Kv1.3-KO) and one wild-type mouse (MBM-WT). KO samples courtesy of Dr. Leonard Kaczmarek, Yale School of Medicine.

Kv1.3 western blots of rat brain membranes(RBM), and adult mouse brain membranes from two Kv1.3 knockout mice (MBM-Kv1.3-KO) and one wild-type mouse (MBM-WT). KO samples courtesy of Dr. Leonard Kaczmarek, Yale School of Medicine.