Kv2.1 K+ channels may play an especially prominent role in determining intrinsic neuronal excitability. Kv2.1 is widely expressed in brain and composes the majority of delayed rectifier K+ current in pyramidal neurons in cortex and hippocampus, and is also widely expressed in interneurons. Dynamic modulation of Kv2.1 localization and function by a mechanism involving activity-dependent dephosphorylation dramatically impacts intrinsic excitability of neurons.
Note: Antibody has been developed by UC Davis under a grant by NIH.
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