Product Details
Catalog Number: MO50022
Applications: WB, IHC, IF
Type: Mouse IgG
Immunogen: Fusion protein amino acids 2-101 of human KCNQ1 (Kv7.1, KvLQT1, accession number P51787). Clone: N37A/10.
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 3784
UniProt: P51787
Downloads: Datasheet (pdf)
Product Sizes
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100 ul$405.00Add to Cart

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). KCNQ1 (Kv7.1), together with its KCNE β subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes

Defects in KCNQ1 are the cause of long QT syndrome type 1 and short QT syndrome type 2. They can result in syncope and sudden death.

Images
Kv7.1 staining of COS-1 cells expressing KCNQ1 (red) and nuclei counter- stained with Hoechst (blue).

Kv7.1 staining of COS-1 cells expressing KCNQ1 (red) and nuclei counter- stained with Hoechst (blue).

Kv7.1 staining of COS-1 cells expressing KCNQ1 (red) and nuclei counter- stained with Hoechst (blue).

Kv7.1 staining of COS-1 cells expressing KCNQ1 (red) and nuclei counter- stained with Hoechst (blue).