Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). KCNQ1 (Kv7.1), together with its KCNE β subunits, plays a pivotal role both in the repolarization of cardiac tissue and in water and salt transport across epithelial membranes
Defects in KCNQ1 are the cause of long QT syndrome type 1 and short QT syndrome type 2. They can result in syncope and sudden death.
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Name Catalog # Size ATPase Na+/K+ transporting alpha 1 MO25023 50 ul KChIP1 K+ channel MO50011 100 ul KChIP2b K+ channel MO50012 100 ul Kir2.1 K+ channel MO50013 100 ul Kir2.2 K+ channel MO50014 100 ul Kv1.1 K+ channel MO50015 100 ul Kv1.2 K+ channel MO50016 100 ul Kv1.3 K+ channel MO50017 100 ul Kv1.4 K+ channel MO50018 100 ul Kv2.1 K+ channel MO50019 100 ul Kv3.1 K+ channel (pSer503) RA25020 100 ul Kv3.1b K+ channel MO50020 100 ul Kv4.2 K+ channel MO50021 100 ul Kv7.2/KCNQ2 K+ channel MO50023 100 ul TREK 1 RA25018 100 ul