Product Details
Catalog Number: MO50023
Applications: WB, IHC, IF
Type: Mouse IgG
Immunogen: Fusion protein amino acids 1-59 (cytoplasmic N-terminus) of human Kv7.2 or KCNQ2 K+ channel (accession number O43526).
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Affinity Purified
Format B: liquid
Species Reactivity: Human, Mouse, Rat
Entrez: 3785
UniProt: O43526
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
100 ul$405.00Add to Cart

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). Kv7.2/KCNQ K+ channels associate with Kv7.3/KCNQ3 K+ channles to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. 

Images: Kv7.2 (dilution 1:100) staining of rat skin sliced into 40μm cryo-sections (red) and counter stained with NF-H (green) doi:10.3389/fnmol.2012.00063.

Defects in Kv7.2 are the cause of benign familial neonatal seizures type 1 (BFNS1). It is also expressed in the peripheral terminals of nociceptive primary afferents.

Images
Kv7.2 (dilution 1:100) staining of rat skin sliced into 40μm cryo-sections (red) and counter stained with NF-H (green) doi:10.3389/fnmol.2012.00063.

Kv7.2 (dilution 1:100) staining of rat skin sliced into 40μm cryo-sections (red) and counter stained with NF-H (green) doi:10.3389/fnmol.2012.00063.

Kv7.2 (dilution 1:100) staining of rat skin sliced into 40μm cryo-sections (red) and counter stained with NF-H (green) doi:10.3389/fnmol.2012.00063.

Kv7.2 (dilution 1:100) staining of rat skin sliced into 40μm cryo-sections (red) and counter stained with NF-H (green) doi:10.3389/fnmol.2012.00063.