FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 35 - 60% amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. FGF basic has been isolated from a number of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. This factor contains four cysteine residues, but reduced FGF basic retains full biological activity, indicating that disulfide bonds are not required for this activity. A variety of forms of FGF basic are produced as a result of N-terminal extensions. These extensions affect localization of FGF basic in cellular compartments but do not affect biological activity. Binding of FGF to heparin or cell surface heparan sulfate proteoglycans is necessary for binding of FGF to high affinity FGF receptors. FGF acidic and basic appear to bind to the same high affinity receptors and show a similar range of biological activities. FGF basic stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. FGF basic induces neuron differentiation, survival, and regeneration. FGF basic also modulates embryonic development and differentiation. These observed in vitro functions of FGF basic suggest FGF basic may play a role in vivo in the modulation of such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, and neuronal function and neural degeneration. Additionally, FGF basic may participate in the production of a variety of pathological conditions resulting from excessive cell proliferation and excessive angiogenesis.
- Product ReviewsGreat customer service and everything went smooth with the order. Product Name: hNP1 Human Neural Progenitor Expansion Kit - (Cat# HN60001) http://bit.ly/1hbpCkD Product Name: Leukemia Inhibitory Factor (LIF), Recombinant Protein - (Cat# PR16101) http://bit.ly/1s7NZe3 Product Name: Recombinant Human FGF basic (146 aa), Recombinant Protein - (Cat# PR15002CF) http://bit.ly/1TT74K3 Organization: Halyard HealthC. Caesar - May 13, 2016 - Rating: 4.0
Leave a review for this product and you could be eligible for a $10 Starbucks gift card.
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size FGF (154), basic PR29000 1 mg FGF (154), basic PR29000 10 ug FGF (154), basic PR29000 50 ug FGF basic (146 aa) PR15002 25 ug FGF basic (157 aa) PR15003 25 ug FGF basic (157 aa), carrier-free PR15003CF 25 ug FGF-1, acidic PR27011 10 ug FGF-1, acidic PR27011 50 ug FGF-1, acidic, Sf9 PR27012 10 ug FGF-1, acidic, Sf9 PR27012 2 ug FGF-19 PR27019 25 ug FGF-19 PR27019 5 ug FGF-2 PR27016 10 ug FGF-2 PR27016 2 ug FGF-2 (Bovine) basic PR27015 10 ug FGF-2 (Bovine) basic PR27015 50 ug FGF-2, basic PR27013 10 ug FGF-2, basic PR27013 50 ug FGF-2, basic, Sf9 PR27014 10 ug FGF-2, basic, Sf9 PR27014 2 ug FGF-22 PR27021 10 ug FGF-22 PR27021 2 ug FGF-8b PR15004 25 ug FGF-8b, carrier-free PR15004CF 25 ug FGF-8c PR15017 25 ug FGF-8c, carrier-free PR15017CF 25 ug FGF-9 PR27017 2 ug FGF-9 PR27017 20 ug FGF-9, mouse PR27018 10 ug FGF-9, mouse PR27018 2 ug FGF-basic/FGF2 (146aa) GMP, CF PR15116CF 25 ug IL-6 PR15059 5 ug ISOKine-bFGF PR80001 10 ug ISOKine-bFGF PR80001 100 ug ISOKine-bFGF PR80001 50 ug KGF Human PR27047 10 ug KGF Human PR27047 2 ug KGF-2 PR27048 25 ug KGF-2 PR27048 5 ug