Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction.
Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins: Activin A (beta A - beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha - beta A) and Inhibin B (alpha - beta B).
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Name Catalog # Size Activin A PR15010 10 ug Activin A PR15010 50 ug Activin A GMP, CF PR15122CF 10 ug Activin A GMP, CF PR15122CF 50 ug Activin A, CF PR15010CF 10 ug Activin A, CF PR15010CF 50 ug Activin AB, CF PR15011CF 5 ug Activin B PR15012 25 ug Activin B PR15012 5 ug Activin B, CF PR15012CF 25 ug Activin B, CF PR15012CF 5 ug TGF Beta1 PR15009 1 ug TGF Beta1 PR27106 10 ug TGF Beta1 PR27106 2 ug TGF Beta2 PR27165 1 ug TGF Beta2 PR27165 5 ug TGF Beta3 PR27164 10 ug TGF Beta3 PR27164 2 ug TGF-alpha, CF PR15016CF 100 ug TGF-alpha, CF PR15016CF 500 ug TGF-beta 1 GMP, CF PR15131CF 10 ug TGFBI PR27154 10 ug TGFBI PR27154 50 ug