Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) or vasculotropin, is a homodimeric 34 - 42 kDa, heparin-binding glycoprotein with potent angiogenic, mitogenic and vascular permeability-enhancing activities specific for endothelial cells. The amino acid sequence of VEGF exhibits primary structural, as well as limited amino acid sequence, homology with that of the A and B chains of PDGF. All eight cysteine residues involved in intra- and inter-chain disulfide bonds are conserved among these growth factors. A cDNA encoding a protein having a 53% amino acid sequence homology in the PDGF-like region of VEGF has been isolated from a human placental cDNA library. This protein, named placenta growth factor (PlGF), is now recognized to be a member of the VEGF family of growth factors. Based on its homology with VEGF, PlGF was also proposed to be an angiogenic factor. Two receptor tyrosine kinases have been described as putative VEGF receptors. Flt-1 (fms-like tyrosine kinase), and KDR (kinase-insert-domain-containing receptor) proteins have been shown to bind VEGF with high affinity.
Note: This VEGF is fully biocative as Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al. (1990) Proc. Natl. Acad. Sci. USA 87:1323. The ED50 for this effect is typically 1.57.5 ng/mL.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size EG-VEGF PR29003 1 mg EG-VEGF PR29003 100 ug EG-VEGF PR29003 20 ug EG-VEGF PR29003 5 ug PEDF PR27157 20 ug PEDF PR27157 5 ug VEGF 120 PR15033 25 ug VEGF 120 PR15033 5 ug VEGF 121 PR15029 25 ug VEGF 121 PR15029 5 ug VEGF 121, CF PR15029CF 25 ug VEGF 121, CF PR15029CF 5 ug VEGF 162 PR15030 25 ug VEGF 162, CF PR15030CF 25 ug VEGF 164 PR15034 25 ug VEGF 164 PR15034 25 ug VEGF 164 PR15035 10 ug VEGF 164 PR15035 50 ug VEGF 164, CF PR15034CF 25 ug VEGF 164, CF PR15034CF 5 ug VEGF 164, CF PR15035CF 10 ug VEGF 164, CF PR15035CF 50 ug VEGF 165 PR15031 10 ug VEGF 165 PR15031 50 ug VEGF 165, CF PR15031CF 10 ug VEGF 165, CF PR15031CF 50 ug VEGF, CF PR15028CF 10 ug VEGF-C PR27170 1 mg VEGF-C PR27170 10 ug VEGF-C PR27170 2 ug VEGF/PIGF Heterodimer PR15032 5 ug VEGF/PIGF Heterodimer, CF PR15032CF 5 ug