The disulfidelinked homodimeric proteins vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) are both members of the VEGF family of growth factors. VEGF and PlGF proteins share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. All eight cysteine residues involved in intra and interchain disulfides are conserved among these growth factors. In their PDGF like regions, VEGF and PlGF also share approximately 53% amino acid sequence similarity. E. coli expressed monomers of PlGF and VEGF can be refolded in vitro to form P lGF/VEGF heterodimers. The purified recombinant VEGF/PlGF heterodimers and VEGF homodimers have potent mitogenic effects on endothelial cells. However, VEGF/PlGF heterodimers display approximately 50fold less mitogenic activity than VEGF homodimers. In contrast, PlGF homodimers have little or no mitogenic effect on endothelial cells. The presence of natural VEGF/PlGF heterodimers in the conditioned media of a number of human tumor cell lines has been demonstrated using a VEGF/PlGF heterodimer specific ELISA.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email firstname.lastname@example.org, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size EG-VEGF PR29003 1 mg EG-VEGF PR29003 100 ug EG-VEGF PR29003 20 ug EG-VEGF PR29003 5 ug PEDF PR27157 20 ug PEDF PR27157 5 ug VEGF PR15028 10 ug VEGF 120 PR15033 25 ug VEGF 120 PR15033 5 ug VEGF 121 PR15029 25 ug VEGF 121 PR15029 5 ug VEGF 121, CF PR15029CF 25 ug VEGF 121, CF PR15029CF 5 ug VEGF 162 PR15030 25 ug VEGF 162, CF PR15030CF 25 ug VEGF 164 PR15034 25 ug VEGF 164 PR15034 25 ug VEGF 164 PR15035 10 ug VEGF 164 PR15035 50 ug VEGF 164, CF PR15034CF 25 ug VEGF 164, CF PR15034CF 5 ug VEGF 164, CF PR15035CF 10 ug VEGF 164, CF PR15035CF 50 ug VEGF 165 PR15031 10 ug VEGF 165 PR15031 50 ug VEGF 165, CF PR15031CF 10 ug VEGF 165, CF PR15031CF 50 ug VEGF, CF PR15028CF 10 ug VEGF-C PR27170 1 mg VEGF-C PR27170 10 ug VEGF-C PR27170 2 ug VEGF/PIGF Heterodimer, CF PR15032CF 5 ug