Dopa decarboxylase (DDC), also known as aromatic amino acid decarboxylase, is a group II decarboxylase.(3) The enzyme catalyzes the decarboxylation of aromatic L-amino acids to produce the corresponding amines. DDC produces the neurotransmitters dopamine and serotonin from L-Dopa and L-5-hydroxytryptophan, respectively. The inhibition of DDC could be used for the treatment of schizophrenia and Parkinson's disease.(4)
1. Ichinose, H. et al., 1989, Biochem. Biophys. Res. Comm. 164:1024 - 1030.
2. Sherald, F. et al., 1973, Anal. Biochem. 56:300 - 305.
3. Sandmeier, E. et al., 1994, Eur. j. Biochem. 221:997 - 1002.
4. Bertoldi, M. et al., 1996, J. Biol. Chem. 271:23954 - 23959.
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