Product Details
Catalog Number: PR15100
Type: Protein
Storage: This product can be stored for up to 1 month at 2°C to 8°C under sterile condition after opening, for up to 3 months at -20°C to -70°C under sterile condition after opening, or for up to 12 months at -20°C to -70°C as supplied. Avoid freeze-thaw cycles.
Shipping: Shipped on Dry Ice
Format A: liquid
Species Reactivity: Rat
Entrez: 24498
UniProt: P20607
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
10 ug$289.00Add to Cart
50 ug$879.00Add to Cart

Interleukin-6 (IL-6) is a pleiotropic, alpha-helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature human IL-6 is 183 amino acids (aa) in length. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise. In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells.

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