Product Details
Catalog Number: PR15109CF
Type: Protein
Storage: This product can be stored for up to 3 months at -20°C to -70°C under sterile condition after opening, or for up to 12 months at -20°C to -70°C as supplied. Avoid freeze-thaw cycles.
Shipping: Shipped on Dry Ice
Format A: liquid
Species Reactivity: Human
Entrez: 11345
UniProt: P60520
Downloads: Datasheet (pdf)
Product Sizes
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50 ug$269.00Add to Cart

Golgi-associated ATPase Enhancer of 16 kDa (GATE-16), also known as Apg8p2 and GABARAPL2, is a 117 amino acid (aa) polypeptide and a member of the Autophagy-related 8 (Atg8) family of proteins. GATE-16/Apg8p2 is best known for its role in autophagy. GATE-16/Apg8p2 covalently attaches to phosphatidylethanolamine (PE) the phagophore (autophagosome precursor) membrane using a Ubiquitin-like conjugation system that includes Ubiquitin-activating (E1)-, Ubiquitin-conjugating (E2)-, and Ubiquitin Ligase (E3)-like enzymes. Here it is involved in the later stages of autophagosome formation. It may also be involved in cargo recruitment to autophagosomes.

His6-GATE-16/Apg8p2 is modified with rhodamine red via primary amine coupling. This results in rhodamine coupled GATE-16/Apg8p2 species with modified lysines as well as the N-terminus. Detection of rhodamine-GATE-16/Apg8p2 occurs with higher efficiency and sensitivity than with antibodies. This protein contains an N-terminal His6 tag.

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