Autophagy related protein 4 homolog B (ATG4B), also known as Autophagy-related Protein 4b (Apg4b) is a cysteine protease and a member of the ATG4 protein family (ATG4A-ATG4D). Human ATG4B/Apg4b shares 95% aa sequence identity with its mouse ortholog. Members of the ATG4 family cleave the C-terminal sequences of the precursor forms of the Autophagy-related Protein 8 (Atg8) family of proteins, including GABARAP, GATE-16, and MAP-LC3. This cleavage exposes the conserved C-terminal glycine that is required for conjugation to phosphatidylethanolamine (PE) in the phagophore membrane and is necessary for autophagosome maturation. Although some ATG4 family members exhibit specificity for certain Atg8 proteins in vitro, ATG4B/Apg4b appears to be relatively non-selective.
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