Product Details
Catalog Number: PR15119CF
Type: Protein
Storage: This product can be stored for up to 1 month at 2°C to 8°C under sterile condition after reconstitution, for up to 3 months at -20°C to -70°C under sterile condition after reconstitution, or for up to 12 months at -20°C to -70°C, as supplied. Avoid freeze-thaw cycles.
Shipping: Ambient
Format B: lyophilized
Species Reactivity: Human
Entrez: 3600
UniProt: P40933
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
25 ug$1,039.00Add to Cart
5 ug$349.00Add to Cart

Interleukin 15 (IL-15) is a widely expressed 14 kDa cytokine that is structurally and functionally related to IL-2 and plays an important role in many immunological diseases. IL-15 binds with high affinity to IL-15 R alpha (4). It binds with lower affinity to a complex of IL-2 R beta and the common gamma chain (gamma c) which are also subunits of the IL-2 receptor complex. IL-15 associates with IL-15 R alpha in the endoplasmic reticulum, and this complex is expressed on the cell surface. IL-15 induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8+ memory cells. An important component of these functions is the ability of IL-15 to induce dendritic cell differentiation and inflammatory activation. IL-15 exhibits anti-tumor activity independent of its actions on NK cells or CD8+ T cells. It also inhibits the deposition of lipid in adipocytes, and its circulating levels are decreased in obesity.

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Bioactivity

GMP-grade Recombinant Human IL-15 stimulates cell proliferation in the MO7e human megakaryocytic leukemic cell line. The ED50 for this effect is 0.3-2.6 ng/mL.

Bioactivity

GMP-grade Recombinant Human IL-15 stimulates cell proliferation in the MO7e human megakaryocytic leukemic cell line. The ED50 for this effect is 0.3-2.6 ng/mL.

SDS-PAGE

1 μg/lane of GMP-grade Recombinant Human IL-15 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 12 kDa.

SDS-PAGE

1 μg/lane of GMP-grade Recombinant Human IL-15 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 12 kDa.

Mass Spectrometry

MALDI-TOF analysis of GMP-grade Recombinant Human IL-15. The major peak corresponds to the calculated molecular mass, 12774 Da. The minor peak at 13006 Da is a matrix-associated artifact of the MALDI-TOF.

Mass Spectrometry

MALDI-TOF analysis of GMP-grade Recombinant Human IL-15. The major peak corresponds to the calculated molecular mass, 12774 Da. The minor peak at 13006 Da is a matrix-associated artifact of the MALDI-TOF.