Product Details
Catalog Number: PR15123CF
Type: Protein
Storage: This product can be stored for up to 1 month at 2°C to 8°C under sterile condition after reconstitution, for up to 3 months at -20°C to -70°C under sterile condition after reconstitution, or for up to 12 months at -20°C to -70°C, as supplied. Avoid freeze-thaw cycles.
Shipping: Ambient
Format B: lyophilized
Species Reactivity: Human
Entrez: 1437
UniProt: P04141
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
10 ug$389.00Add to Cart
50 ug$1,409.00Add to Cart

GM‑CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte‑macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM‑CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM‑CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils. GM‑CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity. It shows clinical effectiveness in ameliorating chemotherapy‑induced neutropenia, and GM‑CSF transfected tumor cells are utilized as cancer vaccines.

Images
Bioactivity

GMP-grade Recombinant Human GM-CSF stimulates pro­liferation of TF‑1 human erythroleukemic cell line. The ED50 is 6-30 pg/mL.

Bioactivity

GMP-grade Recombinant Human GM-CSF stimulates pro­liferation of TF‑1 human erythroleukemic cell line. The ED50 is 6-30 pg/mL.

SDS-PAGE

1 μg/lane of GMP-grade Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

SDS-PAGE

1 μg/lane of GMP-grade Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.

Mass Spectrometry

MALDI-TOF analysis of GMP-grade Recombinant Human GM-CSF. The major peak corresponds to the calculated molecular mass, 14478 Da. The minor peak at 14673 Da is a matrix-associated artifact of the MALDI-TOF.

Mass Spectrometry

MALDI-TOF analysis of GMP-grade Recombinant Human GM-CSF. The major peak corresponds to the calculated molecular mass, 14478 Da. The minor peak at 14673 Da is a matrix-associated artifact of the MALDI-TOF.