Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. TNF-alpha is assembled intracellularly to form a noncovalently linked homotrimer which is expressed on the cell surface. Cell surface TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells, and it can generate its own downstream cell signaling following ligation by soluble TNFR I.
- Product Reviews
- Product Publications
If you've used this product in a publication, let us know. Email email@example.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Name Catalog # Size CNTF PR27005 20 ug CNTF PR27005 5 ug MANF/ARMET, CF PR15079CF 50 ug Midkine PR27145 20 ug Midkine PR27145 5 ug NT-3 GMP, CF PR15120CF 25 ug NT-3 GMP, CF PR15120CF 5 ug NT-4 (Neurotrophin-4) GMP, CF PR15132CF 25 ug NT-4 (Neurotrophin-4) GMP, CF PR15132CF 5 ug PGH-22K Human PR27063 10 ug PGH-22K Human PR27063 2 ug TNF-alpha PR27146 10 ug TNF-alpha PR27146 50 ug Transferrin PR27219 1 gr Transferrin PR27219 100 mg