Product Details
Catalog Number: PR15133CF
Type: Protein
Storage: This product can be stored for up to 3 months at 2°C to 8°C under sterile condition after reconstitution or for at least 6 months at -20°C to -70°C, as supplied. Avoid freeze-thaw cycles.
Shipping: Ambient
Format B: lyophilized
Species Reactivity: Human
Entrez: 3589
UniProt: P20809
Downloads: Datasheet (pdf)
Product Sizes
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50 ug$2,839.00Add to Cart

IL-11 (Interleukin 11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27 and IL-31. In humans, IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF). IL-11 is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts, among other cell types. It is found in the plasma mainly during inflammation, such as that associated with viral infection, cancer, or inflammatory arthritis, and is considered to be primarily anti‑inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis.

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Bioactivity

GMP-grade Recombinant Human IL-11 stimulates cell proliferation of the T11 mouse plasmacytoma cell line. The ED50 for this effect is 0.02-0.12 ng/mL.

Bioactivity

GMP-grade Recombinant Human IL-11 stimulates cell proliferation of the T11 mouse plasmacytoma cell line. The ED50 for this effect is 0.02-0.12 ng/mL.

SDS-PAGE

1 μg/lane of Recombinant Human GMP grade IL-11 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 21 kDa.

SDS-PAGE

1 μg/lane of Recombinant Human GMP grade IL-11 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 21 kDa.