Product Details
Catalog Number: PR27042-25
Type: Protein
Format A: liquid
Species Reactivity: Human
Downloads: Datasheet (pdf)
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25 ug$205.00Add to Cart
The cytokine Macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock. MIF has the unique property of being released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secretion of MIF is tightly regulated and decreases at high, anti-inflammatory steroid concentration.

MIF human Recombinant, fused to His-tag at N-terminus, was cloned into an E. coli expression vector and was purified to apparent homogeneity by using conventional column chromatography techniques. Macrophage Inducing Factor Human Recombinant is a single, glycosylated, polypeptide chain having amino acids from 1-114 and having a molecular mass of 16.6 kDa.

Image: MIF Structure and Sequence..

References:

1. Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility.  Fertil Steril 2007 Jul 19.
2. Increased serum levels of macrophage migration inhibitory factor in patients with Kawasaki disease. Scand J Rheumatol 2007 May-Jun;36(3):222-5.
3. Role of macrophage migration inhibitory factor in corneal neovascularization. Invest Ophthalmol Vis Sci 2007 Aug;48(8):3545-50.
4. Null mutation for Macrophage Migration Inhibitory Factor (MIF) is associated with less aggressive bladder cancer in mice. BMC Cancer 2007 Jul 24;7(1):135.
5. The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal-maternal interface. Semin Immunopathol 2007 Jun;29(2):135-50
6. [Serum levels of macrophage migration inhibitory factor and interleukin-8 in hepatocellular carcinoma patients: their correlations with tumor progression and prognosis.] Zhonghua Gan Zang Bing Za Zhi 2007 Jun;15(6):463-4.

Image: MIF-Human structure and sequence

Images