The term ‘PDGF’ refers to a family of disulphide bond-linked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family – PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist – a short form that is soluble and a long form that is retained by the extracellular matrix.
Image: PDGF-B Structure and Sequence.
1. Correlation between platelet-derived growth factor B chain and bone resorption in rat periapical lesions. J Endod 2007 Jun;33(6):709-11.
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Name Catalog # Size PD-ECGF PR15044 10 ug PDGF - A Human PR27059-20 20 ug PDGF - A Human PR27059-5 5 ug PDGF - AA Human PR27061-10 10 ug PDGF - AA Human PR27061-2 2 ug PDGF - AB Human PR27062-10 10 ug PDGF - AB Human PR27062-2 2 ug PDGF - B Human PR27060-5 5 ug PDGF, CF Human PR15024CF-1 1 ug PDGF, CF Human PR15024CF-4 5 ug PDGF-BB PR15027 50 ug PDGF-BB, CF PR15026CF 10 ug PDGF-BB, CF PR15026CF 50 ug PDGF-BB, CF PR15027CF 50 ug