Recombinant Human CD40 Ligand (hCD40L), TRAP, TNFSF5 or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. CD40 Ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
Note: hCD40L is fully biologically active when compared to a standard. The ED50, as determined using T-47D cells, is <0.04 ug/ml.
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