Product Details
Catalog Number: PR29004
Type: Protein
Storage: Store at -20°C
Shipping: Ambient
Format B: lyophilized
Species Reactivity: Human, Mouse
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
1 mg$6,350.00Add to Cart
10 ug$339.00Add to Cart
100 ug$1,112.00Add to Cart
2 ug$165.00Add to Cart

GDNF promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. GDNF enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. 

Note: This hGDNF is fully biologically active when compared to a standard. The ED50, calculated by the dose-dependent dopamine uptake in rat mesencephalic cultures, was found to be 4-8 ng/ml.


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