P2X2 is a subunit in the family of ion channels activated by extracellular ATP. It was cloned from PC12 cells. P2X2 has two putative transmembrane domains with intracellular N- and C-termini. It can form homomeric channels and heteromeric channels with other members of the family. P2X2 is expressed in brain, spinal cord, sensory and autonomic ganglia as well as in neuroendocrine cells.
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