P2X2 is a subunit in the family of ion channels activated by extracellular ATP. It was cloned from PC12 cells. P2X2 has two putative transmembrane domains with intracellular N- and C-termini. It can form homomeric channels and heteromeric channels with other members of the family. P2X2 is expressed in brain, spinal cord, sensory and autonomic ganglia as well as in neuroendocrine cells.
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- Brigit High, Marie E. Jetté, Mei Li, Vijay R. Ramakrishnan, Matthew Clary, Jeremy Prager, Julia Draf, Thomas Hummel, and Thomas E. Finger. (2023). Variability in P2X Receptor Composition in Human Taste Nerves: Implications for Treatment of Chronic Cough. ERJ Open Research. doi: 10.1183/23120541.00007-2023
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