Product Details
Catalog Number: RA12103
Applications: WB, IHC
Type: Rabbit IgG
Immunogen: ASSEDTLLKDAAKVCR
Storage: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Format B: liquid
Species Reactivity: Human, Mouse, Rat, Porcine
Entrez: 7345
UniProt: P09936
Downloads: Datasheet (pdf)
Product Sizes
SizeList PricePriceCart
150 ul$369.00$209.00Add to Cart
50 ul$165.00$95.00Add to Cart

PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.

It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors.

Images
PGP9.5 staining of epithelial cells in porcine distal colon.

PGP9.5 staining of epithelial cells in porcine distal colon. Nerve fibers immunoreactive for the neural marker PGP 9.5 (red) are in close proximity to both IgA-immunoreactive plasma cells (green) and epithelial cells immunoreactive for SC (blue) in the colonic crypts. Abbreviations: Cr, colonic crypt; L, intestinal lumen; SM, submucosa. Scale bars: A, 100 μm. J Neuroimmunol. Published online 2007 February 21. doi: 10.1016

PGP9.5 staining of epithelial cells in porcine distal colon.

PGP9.5 staining of epithelial cells in porcine distal colon. Nerve fibers immunoreactive for the neural marker PGP 9.5 (red) are in close proximity to both IgA-immunoreactive plasma cells (green) and epithelial cells immunoreactive for SC (blue) in the colonic crypts. Abbreviations: Cr, colonic crypt; L, intestinal lumen; SM, submucosa. Scale bars: A, 100 μm. J Neuroimmunol. Published online 2007 February 21. doi: 10.1016

PGP9.5 staining of rat DRGs (Dilution 1:500)

PGP9.5 staining of rat DRGs (Dilution 1:500)

PGP9.5 staining of rat DRGs (Dilution 1:500)

PGP9.5 staining of rat DRGs (Dilution 1:500)