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| Size | List Price | Price | Cart |
|---|---|---|---|
| 150 ul | $369.00 | Add to Cart | |
| 50 ul | $165.00 | Add to Cart |
PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers. It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCHL1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors. |
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Product Publications
- Sergio Benitez, Alicia Seltzer, Diego Messina, Mabel Foscolo, Sean Patterson, Christian Acosta. (2019). Cutaneous Inflammation Differently Regulates the Expression and Function of Angiotensin II Types 1 and 2 Receptors in Rat Primary Sensory Neurons. Journal of Neurochemistry. doi: 10.1111/jnc.14848
- Saban MR, Davis CA, Avelino A, Cruz F, Maier J, Bjorling DE, Sferra TJ, Hurst RE, Saban R. (2011). VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG. BMC Physiology, 11:16. doi: 10.1186/1472-6793-11-16
- Bianka Brunne, Shanting Zhao, Amin Derouiche, Joachim Herz, Petra May, Michael Frotscher, and Hans H. Bock. (2010). Origin, Maturation and Astroglial Transformation of Secondary Radial Glial Cells in the Developing Dentate Gyrus. Glia, 58(13): 1553–1569. doi: 10.1002/glia.21029
- M Ikeuchi, MD, PhD, SJ Kolker, LA Burnes, RY Walder, PhD, and KA Sluka, PT, PhD. (2008). Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice. Pain, doi: 10.1016/j.pain.2008.01.020
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PGP9.5 staining of epithelial cells in porcine distal colon. Nerve fibers immunoreactive for the neural marker PGP 9.5 (red) are in close proximity to both IgA-immunoreactive plasma cells (green) and epithelial cells immunoreactive for SC (blue) in the colonic crypts. Abbreviations: Cr, colonic crypt; L, intestinal lumen; SM, submucosa. Scale bars: A, 100 μm. J Neuroimmunol. Published online 2007 February 21. doi: 10.1016
PGP9.5 staining of epithelial cells in porcine distal colon. Nerve fibers immunoreactive for the neural marker PGP 9.5 (red) are in close proximity to both IgA-immunoreactive plasma cells (green) and epithelial cells immunoreactive for SC (blue) in the colonic crypts. Abbreviations: Cr, colonic crypt; L, intestinal lumen; SM, submucosa. Scale bars: A, 100 μm. J Neuroimmunol. Published online 2007 February 21. doi: 10.1016
PGP9.5 staining of rat DRGs (Dilution 1:500)
PGP9.5 staining of rat DRGs (Dilution 1:500)