ARC [Apoptosis Repressor with CARD (Caspase-recruitment Domain)] is a 29 kDa cytosolic protein containing an N-terminal CARD joined to a C-terminal region rich in proline and glutamic acid. The expression of human ARC is primarily restricted to skeletal muscle and cardiac tissue. ARC inhibits apoptosis induced by Caspase-8.
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- Andreas Lange, Claudia Kistler, Tanja B. Jutzi, Alexandr V. Bazhin, Claus Detlev Klemke, Dirk Schadendorf and Stefan B. Eichmüller. (2009). Detergent fractionation with subsequent subtractive suppression hybridization as a tool for identifying genes coding for plasma membrane proteins. Experimental Dermatology. Experimental Dermatology, doi: 10.1111/j.1600-0625.2008.00821
- I Mercier, M Vuolo, R Madan4, X Xue, AJ Levalley. (2005). ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer Cell Death and Differentiation, doi: 10.1038/sj.cdd.4401631
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