Ubiquitin is a highly conserved protein that is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation.
Ubiquitin+1 has a carboxyl terminal amino acid sequence that differs from normal ubiquitin due to a frame shift mutation in the mRNA. This ubiquitin+1 form has been noticed in patients with Alzheimer's and Down's syndrome.
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