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Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ug | $365.00 | Add to Cart |
Ubiquitin is a highly conserved protein that is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin+1 has a carboxyl terminal amino acid sequence that differs from normal ubiquitin due to a frame shift mutation in the mRNA. This ubiquitin+1 form has been noticed in patients with Alzheimer's and Down's syndrome. |
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Images
Immunoblots of 2 ng recombinant human Ubiquitin and 2, 1, and 0.5 ng recombinant human Ubiquitin+1. Samples were electrophoresed on 15% gels and immunoblotting was with 1.0 μg/mL anti-Ubiquitin+1. A one minute exposure is shown.
Immunoblots of 2 ng recombinant human Ubiquitin and 2, 1, and 0.5 ng recombinant human Ubiquitin+1. Samples were electrophoresed on 15% gels and immunoblotting was with 1.0 μg/mL anti-Ubiquitin+1. A one minute exposure is shown.